Progesterone is often paired with estrogen in people with a uterus to protect the endometrium

https://www.livebinders.com/b/3698295?tabid=bb7c0a1b-83bd-7098-70f7-58f4ccd25f76

Progesterone is often paired with estrogen in people with a uterus to protect the endometrium and lower the risk of hyperplasia during hormone therapy.